Traditional and non-traditional anticoagulation management during extracorporeal membrane oxygenation

Endogenous glycosaminoglycan anticoagulation in extracorporeal membrane oxygenation

A heparin-like effect was recently described in infants, children, and adults receiving bivalirudin while supported on extracorporeal membrane oxygenation following cardiopulmonary bypass. This is most likely due to endogenous release of glycosaminoglycans from vascular endothelium and mast cells and is associated with longer duration of extracorporeal membrane oxygenation and an increased inci...

Thromboelastography-based anticoagulation management during extracorporeal membrane oxygenation: a safety and feasibility pilot study

BACKGROUND There is no consensus on the management of anticoagulation during extracorporeal membrane oxygenation (ECMO). ECMO is currently burdened by a high rate of hemostatic complications, possibly associated with inadequate monitoring of heparin anticoagulation. This study aims to assess the safety and feasibility of an anticoagulation protocol for patients undergoing ECMO based on thromboe...

Management of Mechanical Ventilation During Extracorporeal Membrane Oxygenation

This chapter explores the best practices of mechanical ventilation during extracorpor‐ eal membrane oxygenation (ECMO) through a detailed discussion of the physiologic theory and clinical evidence. Future areas of study and unanswered questions about mechanical ventilation during ECMO are also delineated.

HEMOSTASIS AND ANTICOAGULATION MONITORING DURING EXTRACORPOREAL MEMBRANE OXYGENATION IN CHILDREN by

Mechanical ventilation during extracorporeal membrane oxygenation

The timing of extracorporeal membrane oxygenation (ECMO) initiation and its outcome in the management of respiratory and cardiac failure have received considerable attention, but very little attention has been given to mechanical ventilation during ECMO. Mechanical ventilation settings in non-ECMO studies have been shown to have an effect on survival and may also have contributed to a treatment...